Visible Light‐induced Functionalization of C−H Bonds: Opening of New Avenues in Organic Synthesis. Issue 6 (16th March 2022)

• Record Type: Journal Article
• Authors: Thakur, Ankita; Manisha, ; Kumar, Inder; Sharma, Upendra
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-16
• Subjects: Visible-light-induced C−H bond functionalization -- Minisci reaction -- hydrogen atom transfer catalysis -- annulation -- EDA complexes; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100804
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: In the last three decades, the resurgence and astonishing evolution of visible light‐mediated unreactive C−H bond functionalization has led to a sustainable and greener approach for introducing various moieties into imperative organic frameworks without the need for substrate preactivation. Unlike traditional electrophilic or nucleophilic reactions, the free radical mechanism of photoredox catalysis opens up new routes to achieve unprecedented C−H bond functionalization. In this context, single‐electron transfer or energy transfer interactions among exogenous photocatalysts, i. e ., TM photocatalysts or organic dye photosensitizers, etc., in their excited state with the targeted substrate, thus generates active radical species, which encompasses the further elusive reaction pathways. This review covers the distinct radical generation methods via photoredox catalysis to trigger the C−H bond cleavage through visible light irradiation. Herein, we provide an overview of progress made in the last five years in visible‐light‐induced C−H bond functionalization, which may help chemists to envision the significant chemical transformations in molecular complexity. Abstract : In this article, recent developments in unprecedented C−H bond functionalization maneuvered through photocatalysis have been highlighted. Selected examples on C−H bond functionalization using the visible light catalysis strategy have been discussed to provide an understanding of the concepts in radical synthetic chemistry. The article mainly focused on the distinct radical generation pathways, representing the potential candidacy of light‐induced C−H functionalization reaction in organic synthesis.