A New Boron 2‐(2′‐pyridyl) Imidazole Complex as a Candidate Photosensitizer for Photodynamic Therapy. Issue 22 (9th June 2022)

• Record Type: Journal Article
• Authors: Ekmekci, Zeynep; Eris, Semanur
• Is Part Of: ChemistrySelect. Volume 7:Issue 22(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-09
• Subjects: BOPIM -- Fluorescence -- Photodynamic therapy -- Singlet oxygen; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202104584
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: In this work, different from the literature, boron 2‐(2′‐pyridyl) imidazole complex (BOPIM) was derived from pyridine ring side to extend π conjugation for the first time. In addition, the core of BOPIM was brominated to increase the capacity of singlet oxygen generation via intersystem crossing to function as a photosensitizer. According to photophysical measurements, the new BOPIM derivative had comparatively large Stokes shift as 111 nm among boron–fluorine derivatives in the literature. Its singlet oxygen generation potential and toxic effect in the dark were investigated in the presence of singlet oxygen trap 1, 3‐Diphenylisobenzofuran (DPBF). According to the obtained results, it was seen that the new BOPIM derivative could be a good photosensitizer for photodynamic therapy. Abstract : A photosensitive molecule is one of the main components required in photodynamic therapy (PDT), and one of the essential specifications is its ability to produce singlet oxygen under appropriate light. In this study, boron 2‐(2′‐pyridyl) imidazole (BOPIM) core, which has many advantages compared to existing many photosensitizers, was functionalized with phenyl group from pyridine side for the first time, and its potential to be as a good photosensitizer candidate for PDT was revealed by its singlet oxygen production ability.