Quinoline‐fused both non‐peripheral and peripheral ZnII and MgII phthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies. (10th May 2022)

• Record Type: Journal Article
• Authors: Yalazan, Halise; Tüzün, Burak; Akkaya, Didem; Barut, Burak; Kantekin, Halit; Yıldırmış, Sermet
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-10
• Subjects: anti‐cholinesterase -- anti‐α‐glucosidase -- molecular docking -- phthalocyanine -- PLIP‐; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6696
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Quinoline‐fused Zn II (ZnPc p /ZnPc np ) and Mg II (MgPc p /MgPc np ) phthalocyanines with four 4‐methylquinolin‐2‐ol (1 ) at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CN p /CN np ) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non‐peripheral Zn II and Mg II phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and α‐glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds. Abstract : In this work, quinoline‐fused Zn II ZnPc p /ZnPc np ) and Mg II (MgPc p /MgPc np ) phthalocyanines with four 4‐methylquinolin‐2‐ol (1) at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized. Then, anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non‐peripheral ZnII and MgII phthalocyanines were investigated. The MgPc np compound has the best inhibitory effect on AChE/BuChE and the highest α‐glucosidase inhibition effect. It is seen that ZnPc p has higher interaction against different cancer proteins than other compounds.