A NaHCO3 Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles. Issue 6 (12th May 2022)

• Record Type: Journal Article
• Authors: Zhou, Yong‐Jun; Yang, Kai; Fang, Yong‐Gan; Luo, Shi‐He; Chen, Qi; Yu, Shi‐Wei; Wang, Zhao‐Yang
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-12
• Subjects: Benzodisulfide heterocyclic compounds -- S−S bond construction -- Transition-metal-free -- Three-component reaction; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202200170
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A facile route for the synthesis of benzodisulfide heterocyclic compounds via a NaHCO3 ‐promoted three‐component reaction between 2‐halophenylacetic acids, elemental sulfur (S8 ) and amines under metal‐free conditions has been demonstrated. This transformation from available starting materials shows good functional group tolerance, and the target compounds can be derivatized for further application. Abstract : A transition metal‐free catalyzed cyclization reaction of 2‐halophenylacetic acid, aromatic amines and elemental sulfur was developed. This synthetic method successfully prepared a variety of benzodithio heterocyclic compounds in high yields via the promotion of simple inorganic base under mild reaction conditions.