Front Cover: Light‐Controllable Binary Switch Activation of CAR T Cells (ChemMedChem 12/2022). (20th June 2022)

• Record Type: Journal Article
• Authors: Kobayashi, Aya; Nobili, Alberto; Neier, Steven C.; Sadiki, Amissi; Distel, Robert; Zhou, Zhaohui Sunny; Novina, Carl D.
• Is Part Of: ChemMedChem. Volume 17:Number 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-20
• Subjects: Immunology -- Cage compounds -- Cancer -- Photolysis -- Fluorescence; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202200309
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Front Cover shows light‐induced activation of CAR T cells. Antibodies are coupled to small molecules protected by ultraviolet‐light‐sensitive cages, which can bind to proteins common to tumors and normal tissues. Only when tumors are exposed to ultraviolet light, cages dissociate from the small molecules, enabling small‐molecule‐specific CAR T cells to attack. In contrast, cages on small molecules prevent CAR T cell attack on normal tissues, which are not exposed to ultraviolet light. Thus, spatiotemporal control will improve the therapeutic index of CAR T cell therapies. Cover design by Rachel Davidowitz. More information can be found in the Research Article by Aya Kobayashi, Alberto Nobili, Carl D. Novina et al.