Compounds with NO Inhibitory Effect from the Rattan Stems of Sinomenium acutum, a Kind of Chinese Folk Medicine for Treating Rheumatoid Arthritis. Issue 6 (27th May 2022)

• Record Type: Journal Article
• Authors: Yu, Kuo; Sun, Ying; Xue, Lu; He, Jingtao; Li, Fangyi; Yin, Maojing; Li, Zheng; Yan, Xiaohui; Guo, Jialiang; Li, Guoqiang; Wang, Chunhua
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-27
• Subjects: Sinomenium acutum -- morphinane alkaloids -- diphenyl ether -- anti-inflammatory potential -- NO inhibitory activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200334
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Three new alkaloids (1 –3 ), one new diphenyl ether (4 ) and fifteen known alkaloids (5 –19 ) were isolated from the rattan stems of Sinomenium acutum . Comprehensive analyses of HR‐ESI‐MS, 1D ( 1 H and 13 C), 2D‐NMR ( 1 H‐ 1 H COSY, HSQC, HMBC, NOESY), circular dichroism (CD), UV and IR revealed the structures and absolute configurations of these new compounds. The structures of other compounds were determined by comparison of their 1 H and 13 C‐NMR data with previous literature reports. By measuring the amount of NO produced, the anti‐inflammatory properties of the isolated compounds were studied. The results showed that compounds 4 and 5 had strong NO inhibitory activity. Abstract :