The electrophysiologic properties of gonadotropin‐releasing hormone neurons. (22nd December 2021)

• Record Type: Journal Article
• Authors: Constantin, Stephanie; Moenter, Suzanne M.; Piet, Richard
• Other Names: Lehman Mike guestEditor.
• Is Part Of: Journal of neuroendocrinology. Volume 34:Number 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-22
• Subjects: action potential -- fertility -- intrinsic properties -- kisspeptin -- luteinizing hormone -- synaptic transmission; Neuroendocrinology -- Periodicals; 616.4
• DOI: 10.1111/jne.13073
• Languages: English
• ISSNs: 0953-8194

Abstract

Abstract: For about two decades, recordings of identified gonadotropin‐releasing hormone (GnRH) neurons have provided a wealth of information on their properties. We describe areas of consensus and debate the intrinsic electrophysiologic properties of these cells, their response to fast synaptic and neuromodulatory input, Ca 2+ imaging correlates of action potential firing, and signaling pathways regulating these aspects. How steroid feedback and development change these properties, functions of GnRH neuron subcompartments and local networks, as revealed by chemo‐ and optogenetic approaches, are also considered. Abstract : For about two decades, recordings of identified gonadotropin‐releasing hormone (GnRH) neurons have provided a wealth of information on their properties. We describe areas of consensus and debate on the intrinsic electrophysiologic properties of these cells, their response to fast synaptic and neuromodulatory input, Ca 2+ imaging correlates of action potential firing, and signaling pathways regulating these aspects. How steroid feedback and development change these properties, functions of GnRH neuron subcompartments and local networks, as revealed by chemo‐ and optogenetic approaches, are also considered.