Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides. Issue 12 (15th June 2022)

• Record Type: Journal Article
• Authors: Liu, Yan-Ping; Yu, Xiao-Mei; Qiao, Ze-Hua; Jiang, Bo; Xie, Lan; Tang, Hao-Xuan; Liang, Xiao; Fu, Yan-Hui
• Is Part Of: Natural product research. Volume 36:Issue 12(2022)
• Page Start: 3078
• Page End: 3084
• Publication Date: 2022-06-15
• Subjects: Mappianthus iodoides -- cadinane-type sesquiterpene -- mappianiodene -- anti-inflammatory effects -- anti-HIV activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1956921
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Eight cadinane-type sesquiterpenes, including a new cadinane-type sesquiterpene, named as mappianiodene (1 ), and seven known analogues (2 –8 ), were isolated and identified from the stems and leaves of Mappianthus iodoides . The chemical structure and absolute configurations of 1 was elucidated by extensive spectral methods and the known compounds were identified by comparing their experimental spectral data with the reported spectral data in the literature. The anti-inflammatory and anti-HIV activities of those isolated cadinane-type sesquiterpenes were tested. As a result, cadinane-type sesquiterpenes 1 –8 displayed notable inhibitory effects on NO (nitric oxide) production with IC50 values equivalent to that of the hydrocortisone. Moreover, compounds 1 –8 exhibited pronounced anti-HIV-1 reverse transcriptase (RT) activities with the EC50 values in range of 0.17 to 9.28 µM. Graphical abstract: UF0001