An update on novel multiple myeloma targets. Issue 6 (3rd June 2022)

• Record Type: Journal Article
• Authors: Offidani, Massimo; Corvatta, Laura; Morè, Sonia; Manieri, Maria Valentina; Olivieri, Attilio
• Is Part Of: Expert review of hematology. Volume 15:Issue 6(2022)
• Page Start: 519
• Page End: 537
• Publication Date: 2022-06-03
• Subjects: Multiple myeloma -- monoclonal antibodies -- bispecific antibodies -- antibody-drug conjugates -- CAR T cell therapy -- targets; Hematology -- Periodicals; 616.15005
• DOI: 10.1080/17474086.2022.2085088
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: Introduction: Despite therapeutic progress, leading to a significant improvement of outcome, multiple myeloma (MM) remains a difficult to treat hematologic disease due to its biological heterogeneity and clinical complexity. Areas covered: Treatment of patients refractory and resistant to all classes of agents used in newly diagnosed MM is becoming a relevant problem for every hematologist. New generation immunotherapies, such as conjugated mAb, bispecific mAbs and CAR-T cells, targeting novel molecules as BCMA, have showed relevant results in very advanced MM. In the same setting, small molecules, such as selinexor and melflufen, also proved to be effective. We are currently waiting for the results of under evaluation personalized therapy, directed against specific gene mutations or signaling pathways, responsible for disease progression. Expert Opinion: In the near future, many therapeutic strategies will become available for MM and the challenge will be to position each approach in order to cure, maintaining a good quality of life in these patients.