Meta-analysis on prevalence of vaginal group B streptococcus colonization and preterm births in India. (3rd August 2022)

• Record Type: Journal Article
• Authors: Ashary, Nancy; Singh, Abhishek; Chhabria, Karisma; Modi, Deepak
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 15(2022)
• Page Start: 2923
• Page End: 2931
• Publication Date: 2022-08-03
• Subjects: Bacteria -- Group B Streptococcus -- GBS -- pregnancy -- preterm -- India -- premature rupture of membranes -- PROM -- intrapartum antibiotics -- meta-analysis -- systematic review -- infection; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2020.1813705
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: Preterm birth is a major cause of neonatal morbidity and mortality. Vaginal colonization of Group B Streptococci (GBS) is associated with increased risk of preterm birth. However, the association of GBS colonization and preterm births in the Indian context remains an unrecognized problem. Data sources: Data was collected using various online search tools from 36 (1981–2019) Indian studies comprising 9778 cases. Method of study selection: Studies reporting the prevalence of GBS colonization in the Indian population were included. Tabulation, Integration, and Results: The prevalence of GBS colonization in pregnant Indian women was estimated to be 7.8% (763/9778) with wide heterogeneity across studies. The prevalence of GBS was 7.4% when culture methods were used and 11.6% with use of immunological methods. The detection rate of GBS almost doubled when enrichment was used in the culture method (8.1 vs. 5%). The risk of preterm delivery was higher (OR 7.9) among women with GBS colonization as compared to those without GBS. Conclusions: As compared to the western population, there is low prevalence of GBS colonization among Indian pregnant women; however, the risk of preterm births with GBS colonization is higher. There is a need to implement a universal GBS screening program prior to intrapartum antibiotic prophylaxis in women experiencing preterm births.