Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity. Issue 12 (15th June 2022)

• Record Type: Journal Article
• Authors: Song, Min; Xiao, Tong; Wu, Qiu-Shuang; Kwok, Hang Fai; Chan, Ging; Lin, Li-Gen; Zhang, Xiao-Qi; Ye, Wen-Cai; He, Sheng-Jiang; Zhang, Qing-Wen
• Is Part Of: Natural product research. Volume 36:Issue 12(2022)
• Page Start: 3085
• Page End: 3094
• Publication Date: 2022-06-15
• Subjects: Cephalotaxus oliveri -- biflavonoids -- α-glucosidase inhibitory activity -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1958328
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new biflavonoids, umcephabiovins C − E (1 − 3 ), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri . Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 − 3 exhibited significant α -glucosidase inhibitory activity with IC50 values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 μ M, respectively. Compound 11 showed moderate cytotoxicity against the BaF3/T315I cell line. Graphical Abstract: UF0001