Biomolecule-guided co-localization of intermolecular G-rich strands for the construction of a tetramolecular G-quadruplex sensing strategy. Issue 49 (27th May 2022)

• Record Type: Journal Article
• Authors: Hu, Changjia; Jin, Yanwen; Yang, Peng; Zhou, Rongxing; Xia, Lingying; Du, Lijie; Chen, Junbo; Cheng, Nansheng; Hou, Xiandeng
• Is Part Of: Chemical communications. Volume 58:Issue 49(2022)
• Page Start: 6914
• Page End: 6917
• Publication Date: 2022-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01587k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We herein introduce the principle of proximity assay into tetramolecular G-quadruplexes guided by various biomolecules for the construction of a sensing strategy. Abstract : We herein introduce the principle of proximity assay into tetramolecular G-quadruplexes guided by various biomolecules for the construction of a sensing strategy. Our strategy is based on the co-localization of intermolecular G-rich strands guided by a recognition event of a specific biomolecule to its corresponding affinity ligand. In such case, the local concentration among intermolecular strands is significantly increased to trigger the following self-assembly that served as the peroxidase-mimicking activity. This strategy is versatile, homogenous and adaptable to different types of biomolecules.