Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction. Issue 12 (26th May 2022)

• Record Type: Journal Article
• Authors: Porcheddu, Andrea; Mocci, Rita; Brindisi, Margherita; Cuccu, Federico; Fattuoni, Claudia; Delogu, Francesco; Colacino, Evelina; D'Auria, Maria Valeria
• Is Part Of: Green chemistry. Volume 24:Issue 12(2022)
• Page Start: 4859
• Page End: 4869
• Publication Date: 2022-05-26
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d2gc00724j
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea. Abstract : We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea. The solvent-free procedure shows versatility and wide scope; it applies to a broad range of arylhydrazines and carbonyl compounds, leading to variously decorated indoles and indolenines. Upon suitable modification, the methodology can also allow preparing compounds of pharmaceutical interest.