De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface. Issue 23 (6th June 2022)

• Record Type: Journal Article
• Authors: Luo, Wei; Noguchi, Hironaga; Chen, Chen; Nakamura, Yoshiki; Homma, Chishu; Zozulia, Oleksii; Korendovych, Ivan V.; Hayamizu, Yuhei
• Is Part Of: Nanoscale. Volume 14:Issue 23(2022)
• Page Start: 8326
• Page End: 8331
• Publication Date: 2022-06-06
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d2nr01507b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : De novo designed peptides self-assembled on a graphite surface to produce highly robust and active electrocatalysts and promote peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. Abstract : Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite–peptide–hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new approach to creating complex electrocatalytic assemblies will yield highly efficient and practically applicable electrocatalysts.