A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome. Issue 50 (1st June 2022)

• Record Type: Journal Article
• Authors: Wang, Cheng; Wang, Jiaxin; Xue, Ke; Xiao, Minghui; Sun, Zhencheng; Zhu, Chunlei
• Is Part Of: Chemical communications. Volume 58:Issue 50(2022)
• Page Start: 7058
• Page End: 7061
• Publication Date: 2022-06-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc02230c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A receptor-targeting AIE photosensitizer is reported for selective killing of Gram-positive bacteria with real-time feedback on the therapeutic outcome. Abstract : A receptor-targeting AIE photosensitizer (CE-TPA) is synthesized by conjugating cephalothin with a cationic D–A type AIE photosensitizer for selective killing of Gram-positive bacteria over Gram-negative bacteria and normal mammalian cells. By virtue of the strong photosensitization capability, CE-TPA exhibits efficient killing against Gram-positive methicillin-resistant Staphylococcus aureus . More importantly, the photodynamic bactericidal outcome can be conveniently reflected in a real-time fashion by the polarity-sensitive property of CE-TPA.