(Hyper)tension release by N-terminal acetylation. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Aksnes, Henriette; Drazic, Adrian; Arnesen, Thomas
• Is Part Of: Trends in biochemical sciences. Volume 40:Issue 8(2015)
• Page Start: 422
• Page End: 424
• Publication Date: 2015-08
• Subjects: N-terminal acetylation -- N-end rule -- protein degradation -- G-protein signaling -- blood pressure regulation -- Rgs2; Biochemistry -- Periodicals; 572
• DOI: 10.1016/j.tibs.2015.05.003
• Languages: English
• ISSNs: 0968-0004

Abstract

Abstract : A recent study links N-terminal acetylation and N-end rule degradation to blood pressure regulation. N-terminal mutants of Rgs2, a key G-protein regulator, are differentially processed by N-terminal acetyltransferases and the two branches of the N-end rule pathway. This leads to an imbalance in the signaling governing blood pressure.