Hedgehog Signaling Pathway Proteins in Prognosis of Pancreatic Ductal Adenocarcinoma and Its Differentiation From Chronic Pancreatitis. Issue 3 (March 2022)

• Record Type: Journal Article
• Authors: Winter, Katarzyna; Dzieniecka, Monika; Strzelczyk, Janusz; Wągrowska-Danilewicz, Małgorzata; Danilewicz, Marian; Zatorski, Hubert; Małecka-Wojciesko, Ewa
• Is Part Of: Pancreas. Volume 51:Issue 3(2022)
• Page Start: 219
• Page End: 227
• Publication Date: 2022-03
• Subjects: pancreatic ductal adenocarcinoma -- chronic pancreatitis -- PDAC -- Hedgehog signaling pathway -- prognostic factor; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000002001
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: The Hedgehog signaling pathway (Hh) probably plays a role in development and progression of pancreatic ductal adenocarcinoma (PDAC). Methods: In our study, 114 patients (83 with PDAC and 31 with chronic pancreatitis [CP]) after pancreatic surgery were enrolled. The immunoexpression of Sonic hedgehog (Shh), Smoothened (Smo), and Glioblastoma transcription factor 1 (Gli1) and Ki-67 were detected in tissue specimens. Results: Mean (standard deviation) immunoexpression of all Hh pathway molecules was significantly higher in PDAC than in CP patients: Shh, 2.24 (0.57) versus 1.17 (0.25) ( P < 0.01); Smo, 2.62 (0.34) versus 1.21 (0.23) ( P < 0.01); and Gli1, 1.74 (0.74) versus 1.15 (0.72) ( P < 0.01). Patients with a lower expression level ( z score <0) of Shh and Ki-67 have longer overall survival when compared with z score >0 (15.97 vs 8.53 months [ P = 0.0087] and 15.20 vs 5.53 months [ P = 0.0004], respectively). In addition, Shh sensitivity in PDAC detection was 84.3%; specificity, 93.5%; positive predictive value, 97.2%; and negative predictive value, 69%. Conclusions: Our results suggest the prognostic role of the Hh pathway in PDAC and a role in the differential diagnosis with CP.