Genetic exchange and reassignment in Porphyromonas gingivalis. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Olsen, Ingar; Chen, Tsute; Tribble, Gena D
• Is Part Of: Journal of oral microbiology. Volume 10:Issue 1(2018)
• Publication Date: 2018-01-01
• Subjects: Porphyromonas gingivalis -- adaptability -- survival -- periodontitis -- keystone pathogen hypothesis -- homeostasis -- dysbiosis; Mouth -- Microbiology -- Periodicals; Medical microbiology -- Periodicals; Mouth Diseases -- microbiology; Mouth -- microbiology; Medical microbiology; Mouth -- Microbiology; Oral Pathology; Microbiology; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.31
• DOI: 10.1080/20002297.2018.1457373
• Languages: English
• ISSNs: 2000-2297

Abstract

ABSTRACT: Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of P. gingivalis . The present review discusses how the exchange of alleles can convert this bacterium from commensalistic to pathogenic and potentially shapes the host-microbe environment from homeostasis to dysbiosis. It is likely that genotypes of P. gingivalis with increased pathogenic adaptations may spread in the human population with features acquired from a common pool of alleles. The exact molecular mechanisms that trigger this exchange are so far unknown but they may be elicited by environmental pressure.