Biological Evaluation of Azo‐ and Imino‐Based Carboxylate Triphenyltin(IV) Compounds. Issue 11 (11th February 2020)

• Record Type: Journal Article
• Authors: Paul, Anup; Hazra, Susanta; Guedes da Silva, M. Fátima C.; Pombeiro, Armando J. L.
• Other Names: Pettinari Claudio guestEditor.
• Is Part Of: European journal of inorganic chemistry. Issue 11/12(2020)
• Page Start: 930
• Page End: 941
• Publication Date: 2020-02-11
• Subjects: Carboxylic acids -- Carboxylate ligands -- Tin -- Biological activity -- Structure‐activity relationships; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201901177
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : Azo (‐N=N‐)‐ and imino (‐C=N‐)‐carboxylate triphenyltin(IV) compounds, which are well known for their promising biological activities, are usually synthesized by reacting a triphenyltin(IV) compound (oxide, hydroxide or chloride) with a suitably substituted carboxylic acid, under appropriate conditions. Their biological properties are influenced by the type/position of the functional azo or imino group in the carboxylate ligand skeleton. They are very effective in anticancer studies, being often better than the standard drug cisplatin in terms of cytotoxicity. A few of the azo‐appended carboxylate triphenyltin(IV) compounds also display anti‐bacterial, anti‐fungal and anti‐diabetic activities. The present manuscript highlights the syntheses, structures, and biological (i.e., anti‐cancer, anti‐bacterial, anti‐fungal and anti‐diabetic) activities of such triphenyltin(IV) compounds. Abstract : The review highlights the syntheses, structures, and biological properties of organotin(IV) benzoates containing –N=N– (azo group) or –C=N– (imine group) appended skeletons.