Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient. Issue 1 (23rd February 2021)

• Record Type: Journal Article
• Authors: Dunleavy, Katie A; Ungaro, Ryan C; Manning, Laura; Gold, Stephanie; Novak, Joshua; Colombel, Jean-Frederic
• Is Part Of: Crohn's & colitis 360. Volume 3:Issue 1(2021)
• Publication Date: 2021-02-23
• Subjects: vitamin C deficiency -- inflammatory bowel disease -- scurvy; Crohn's disease -- Periodicals; Colitis -- Periodicals; 616.344
• DOI: 10.1093/crocol/otab009
• Languages: English
• ISSNs: 2631-827X

Abstract

Abstract: Background: Micronutrient deficiencies are common in patients with inflammatory bowel disease (IBD). To date, the literature has focused on vitamin D, vitamin B12, and iron deficiencies. Methods: We report a case series of 20 patients with IBD and vitamin C deficiency treated at a single tertiary care center. Results: Sixteen (80%) patients had symptoms of clinical scurvy, including arthralgia, dry brittle hair, pigmented rash, gingivitis, easy bruising, and/or brittle nails. Eighteen patients underwent a nutritional assessment, 10 (56%) patients reported complete avoidance of fruits and vegetables, and 3 (17%) reported reduced intake of fruits and vegetables. Conclusions: Vitamin C deficiency should be considered in IBD patients, particularly those with reduced fruit/vegetable intake, as it can lead to significant signs and symptoms. Lay Summary: Nutritional deficiencies are common in patients with inflammatory bowel disease (IBD). This case series of patients with vitamin C deficiency and IBD highlights the signs/symptoms of vitamin C deficiency and the need for appropriate dietary counseling in patients with IBD.