A concise total synthesis of hymenialdisine. Issue 23 (3rd June 2015)

• Record Type: Journal Article
• Authors: Saleem, Rahman Shah Zaib; J. Tepe, Jetze
• Is Part Of: Tetrahedron letters. Volume 56:Issue 23(2015)
• Page Start: 3011
• Page End: 3013
• Publication Date: 2015-06-03
• Subjects: Natural product -- Hymenialdisine -- Total synthesis -- Heterocycles -- Antitumor agents; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.10.022
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: The synthesis of hymenialdisine has offered challenges that included the formation of the regio-isomers upon monobromination, atom-scrambling in the cyclization step, and low to moderate yields in the last steps. We herein present a short and concise (6 overall steps), high yielding route (44% overall yields) for this biologically interesting natural product that addresses these issues and avoids the use of any protecting groups.