Triethysilyl enol ethers in the synthesis of carbapenem precursors. Issue 23 (3rd June 2015)

• Record Type: Journal Article
• Authors: Nguyen, Thu Q.; Chai, Weirui; Gu, Jane; Cook, Katie; Kim, Eugene; Goetz, Sam; Farni, Zach; Chepuru, Monica; Cox, Melina; Nguyen, Pauline; Raja, Hashim; Magistrado, Patrick; Michael, Faith; Oelschlaeger, Peter; Buynak, John D.
• Is Part Of: Tetrahedron letters. Volume 56:Issue 23(2015)
• Page Start: 3385
• Page End: 3389
• Publication Date: 2015-06-03
• Subjects: Antibiotic -- Carbapenem -- β-Lactam -- Silyl enol ether -- Lewis acid; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.01.025
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA.