M6A modification: A mechanism for protecting hematopoietic development in mammals. (9th October 2020)

• Record Type: Journal Article
• Authors: Gao, Jiayin; Yan, Jialong; Huang, Zhen; Chen, Linxi
• Is Part Of: Cell biology international. Volume 45:Number 1(2021)
• Page Start: 58
• Page End: 60
• Publication Date: 2020-10-09
• Subjects: dsRNA -- hematopoietic development -- innate immune response -- M6A modification; Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1002/cbin.11471
• Languages: English
• ISSNs: 1065-6995

Abstract

Abstract: N 6 ‐methyladenosine (m 6 A) is one of the most common internal modifications in messenger RNA, which is necessary for cell physiological activities. A recent study shows that during mammalian hematopoietic development, loss of m 6 A modification leads to the aberrant production of double‐stranded RNA, which results in the abnormal activation of innate immune response, and ultimately leads to hematopoietic failure. Accordingly, m 6 A modification provide us an attractive direction for us to understand mammalian hematopoietic development and innate immune response.