3D high‐resolution diffusion‐weighted MRI at 3T: Preliminary application in prostate cancer patients undergoing active surveillance protocol for low‐risk prostate cancer. Issue 2 (11th March 2015)

• Record Type: Journal Article
• Authors: Nguyen, Christopher; Sharif‐Afshar, Ali‐Reza; Fan, Zhaoyang; Xie, Yibin; Wilson, Sidney; Bi, Xiaoming; Payor, Lucas; Saouaf, Rola; Kim, Hyung; Li, Debiao
• Is Part Of: Magnetic resonance in medicine. Volume 75:Issue 2(2016:Feb.)
• Page Start: 616
• Page End: 626
• Publication Date: 2015-03-11
• Subjects: diffusion preparation -- bSSFP -- diffusion‐weighted -- prostate cancer -- MRI; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25609
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To improve spatial resolution and image quality of diffusion‐weighted (DW) MRI in detecting low‐risk prostate cancer (lrPC) in patients undergoing active surveillance protocol (AS‐PC), we propose the application of a diffusion‐prepared balanced steady‐state free precession (bSSFP) technique capable of multishot acquisition. Methods: Diffusion‐prepared bSSFP was compared with single‐shot DW echo planar imaging (SS‐DW‐EPI) at two prescribed resolutions (2.1 × 2.1 × 3.5mm 3, 0.9 × 0.9 × 3.5 mm 3 ) in nine healthy subjects and nine AS‐PC patients. Geometric distortion and susceptibility artifacts were quantitatively assessed in all subjects. In AS‐PC patients, lesion detection via blinded multiparametric MRI including T1‐weighted, T2‐weighted, dynamic contrast‐enhanced imaging, and along with either of two DW methods were evaluated against 12‐point biopsy. Results: Geometric distortion and susceptibility artifacts were significantly less for diffusion‐prepared bSSFP at both prescribed spatial resolutions than SS‐DW‐EPI. Apparent diffusion coefficients of healthy prostate tissue were concordant between the two DW methods at both spatial resolutions. In AS‐PC patients, multiparametric MRI with diffusion‐prepared bSSFP had greater sensitivity (94%, 63%), accuracy (76%, 67%), positive‐predictive value (54%, 48%), negative‐predictive value (97%, 82%), and area under the curve (0.80, 0.67) than with SS‐DW‐EPI. Conclusions: The proposed diffusion‐prepared technique with higher spatial resolution and improved image quality over SS‐DW‐EPI resulted in better multiparametric MRI detection of lrPC in AS‐PC patients. Magn Reson Med 75:616–626, 2016. © 2015 Wiley Periodicals, Inc.