The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase. Issue 7 (3rd July 2019)

• Record Type: Journal Article
• Authors: Nitta, Yoko; Ito, Hideyuki; Komori, Hirohumi; Ueno, Hiroshi; Takeshima, Daiki; Ito, Mikiko; Sakaue, Motoyoshi; Kikuzaki, Hiroe
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 7(2019)
• Page Start: 1315
• Page End: 1318
• Publication Date: 2019-07-03
• Subjects: Histamine -- ellagitannin oligomer -- Rosaceae -- Rosa gallica -- herbal tea; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1606695
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation. Abbreviations: HDC, histidine decarboxylase; Me2 CO, acetone; EtOAc, ethyl acetate