A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis. Issue 7 (3rd July 2019)

• Record Type: Journal Article
• Authors: Kariu, Toru; Ikeda, Tsuyoshi; Nakashima, Keisuke; Potempa, Jan; Imamura, Takahisa
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 83:Issue 7(2019)
• Page Start: 1382
• Page End: 1384
• Publication Date: 2019-07-03
• Subjects: Porphyromonas gingivalis -- gingipains -- flavonoids -- epimedokoreanin B; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2019.1597615
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens.