Flavonoid metabolism: the interaction of metabolites and gut microbiota. Issue 4 (3rd April 2018)

• Record Type: Journal Article
• Authors: Murota, Kaeko; Nakamura, Yoshimasa; Uehara, Mariko
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 82:Issue 4(2018)
• Page Start: 600
• Page End: 610
• Publication Date: 2018-04-03
• Subjects: Flavonoid -- phase II metabolism -- ring-fission products -- equol -- microbial metabolism; AhR: aryl hydrocarbon receptor -- ALDH: aldehyde dehydrogenase -- CBG: cytosolic β-glucosidase -- COMT: catechol-O-methyltransferases -- DHD: dihydrodaidzein -- l-DDRC: DHD racemase -- l-DHDR: DHD reductase -- O-DMA: O-desmethylangolensin -- DOPAC: 3, 4-dihydroxyphenylacetic acid -- l-DZNR, NADP(H)-dependent daidzein reductase -- FOS: fructooligosaccharides -- Keap1: Kelch-like erythroid cell-derived protein 1 -- LPH: lactase-phlorizin hydrolase -- MCT: monocarboxylic acid transporter -- Nrf2: NFE2-related factor 2 -- OPAC: 3-hydroxyphenylacetic acid -- OVX: ovariectomized -- PCA: 3, 4-dihydroxybenzoic (protocatechuic) acid -- Q3G: quercetin 3-O-glucoside -- Q4ʹG: quercetin 4ʹ-O-glucoside -- SGLT1: sodium-glucose co-transporter type 1 -- SULT: sulfotransferases, UGT: uridine-5ʹ-diphosphate-glucuronosyltransferases -- THD: tetrahydrodaidzein -- l-THDR: THD reductase; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2018.1444467
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota. Abstract: : The intestinal microbiota plays important roles in the metabolism of flavonoids. Various chemical forms of flavonoids are present in the systemic circulation.