Tricin derivatives as anti-inflammatory and anti-allergic constituents from the aerial part of Zizania latifolia. Issue 5 (4th May 2015)

• Record Type: Journal Article
• Authors: Lee, Seung-Su; Baek, Yoon-Su; Eun, Cheong-Su; Yu, Mi-Hee; Baek, Nam-In; Chung, Dae-kyun; Bang, Myun-Ho; Yang, Seun-Ah
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 5(2015)
• Page Start: 700
• Page End: 706
• Publication Date: 2015-05-04
• Subjects: Zizania latifolia -- new flavonolignan -- tricin -- salcolin -- anti-allergy -- anti-inflammation; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.997184
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Methanol extract of Zizania latifolia was partitioned with EtOAc, n -BuOH, and H2 O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, tricin (1 ), salcolin A (2 ), salcolin B (3 ), and salcolin C (4 ), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be tricin-4′- O -[ erythro - β -guaiacyl-(7″- O -methyl)-glyceryl] ether and was named salcolin D (5 ) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2–5, tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than tricin. In particular, salcolin D (5 ) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as β -hexosaminidase release in IgE-sensitized RBL-2H3 cells. These results suggest that the presence of tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia . Graphical abstract: : Chemical structures of the isolated compounds 1 –5 from the Z. latifolia and Key gHMBC correlations for compound 5