Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet. Issue 11 (2nd November 2017)

• Record Type: Journal Article
• Authors: Hira, Tohru; Yanagihara, Kurumi; Koga, Toshiki; Takahashi, Keisuke; Nagura, Taizo; Uchino, Hirokatsu; Hara, Hiroshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 81:Issue 11(2017)
• Page Start: 2186
• Page End: 2194
• Publication Date: 2017-11-02
• Subjects: difructose anhydride III -- raffinose -- fructooligosaccharides -- diet-induced obesity -- GLP-1; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2017.1373591
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion. Abstract : : Supplementation of 3% DFA III attenuated energy intake of rats fed a obesogenic a high-fat/high-sucrose diet.