Oral supplementation of Bifidobacterium longum strain BR-108 alters cecal microbiota by stimulating gut immune system in mice irrespectively of viability. Issue 7 (3rd July 2018)

• Record Type: Journal Article
• Authors: Makioka, Yuko; Tsukahara, Takamitsu; Ijichi, Tetsuo; Inoue, Ryo
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 82:Issue 7(2018)
• Page Start: 1180
• Page End: 1187
• Publication Date: 2018-07-03
• Subjects: Gut microbiota -- heat-killed Bifidobacterium -- immunostimulation -- mouse; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2018.1451738
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Effect on cecal microbiota and gene expression of various cytokines in ileal Peyer's patches and cecal tissues were compared between viable and heat-killed Bifidobacterium longum strain BR-108 (BR-108) using a mouse model. Irrespectively of viability, oral supplementation of BR-108 altered the cecal microbiota and stimulated gene expression of cytokines such as IL-6 and IL-10 in ileal Peyer's patches and cecal tissue of mice. In addition, BR-108 supplementation significantly affected the relative abundance of bacterial genera and family, Oscillospira, Bacteroides and S24-7. The abundance of these bacterial genera and family strongly correlated with gene expression induced by BR-108. This study demonstrated that the effect of heat-killed BR-108 on the mouse cecal microbiota is similar to that of viable BR-108, most likely due to stimulation of the gut immune system by both heat-killed and viable BR-108 is also similar. Abstract : : Oral administration of Bifidobacterium longum strain BR-108 altered mouse cecal microbiota irrespectively of viability.