Α-Defensin 5 gene expression is regulated by gut microbial metabolites. Issue 2 (1st February 2017)

• Record Type: Journal Article
• Authors: Sugi, Yutaka; Takahashi, Kyoko; Kurihara, Kenta; Nakano, Kou; Kobayakawa, Tetsuro; Nakata, Kazuaki; Tsuda, Masato; Hanazawa, Shigemasa; Hosono, Akira; Kaminogawa, Shuichi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 81:Issue 2(2017)
• Page Start: 242
• Page End: 248
• Publication Date: 2017-02-01
• Subjects: α-defensin -- intestinal epithelial cells -- gut microbiota -- metabolite; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2016.1246175
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: α-Defensin 5 is important to both maintenance of a gut microbiota and host immunity. While previous reports have shown that gut bacteria are able to upregulate α-defensin 5 through Toll-like receptor signaling, we demonstrate here that α-defensin 5 expression can also be regulated by microbial metabolites. Among these, lactate appeared to significantly suppress α-defensin 5 gene transcription. Actually, fractions of <3 kD compounds obtained from the ceca of SPF mice were suppressed α-defensin 5 gene transcription at specific concentrations. Our results also suggest that cecal content may include as yet unidentified factors that can enhance α-defensin 5 expression. Our data point to a novel function for the gut microbial metabolites in controlling the expression of antimicrobial peptides in the intestine. Graphical abstract: :