Overview of the centriole architecture. (February 2021)

• Record Type: Journal Article
• Authors: LeGuennec, Maeva; Klena, Nikolai; Aeschlimann, Gabriel; Hamel, Virginie; Guichard, Paul
• Is Part Of: Current opinion in structural biology. Volume 66(2021)
• Page Start: 58
• Page End: 65
• Publication Date: 2021-02
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2020.09.015
• Languages: English
• ISSNs: 0959-440X

Abstract

Highlights: Centrioles are giga-dalton macromolecular assemblies with distinctive subelements. Cryo-tomography unveils the native architecture of the centriole. Comparison between species highlights the conservation and differences of the substructures. Abstract : The centriole is a magnificent molecular assembly of several giga-daltons, one of the largest of the eukaryotic cell, and whose atomic structure remains unsolved to date. However, numerous electron microscopy, cryo-tomography, and super-resolution studies now make it possible to establish a global architectural view of it with its different sub-regions. These analyses broaden our understanding by providing additional informations to cell biology and structural biology approaches. In this review, we describe current knowledge on the overall organization of the centriole. We will highlight each sub-structural element, their differences between species and their putative protein composition. We will conclude on the current limitations that still take us away from a complete atomic view of the centriole architecture.