Back Cover: Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins (Angew. Chem. Int. Ed. 24/2019). Issue 24 (22nd May 2019)

• Record Type: Journal Article
• Authors: Liu, Feng; Wang, Hua; Li, Suhua; Bare, Grant A. L.; Chen, Xuemin; Wang, Chu; Moses, John E.; Wu, Peng; Sharpless, K. Barry
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 24(2019)
• Page Start: 8242
• Page End: 8242
• Publication Date: 2019-05-22
• Subjects: bioconjugation -- click chemistry -- DNA encoded libraries -- protein modification -- SuFEx; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201906154
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : SuFEx goes biology New biocompatible SOF4 ‐based SuFEx reactions operating at low concentration in aqueous solution under mild pH and temperature conditions provide access to asymmetric and trisubstituted products at the sulfur(VI) center with versatile S−N and S−O connectivity. The SuFEx bioconjugation of iminosulfur oxydifluorides to either BSA protein or to single‐stranded DNA is demonstrated. Details can be found in the Communication by K. B. Sharpless et al. on page 8029.