High‐Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads. (7th May 2019)

• Record Type: Journal Article
• Authors: Tu, Noah P.; Dombrowski, Amanda W.; Goshu, Gashaw M.; Vasudevan, Anil; Djuric, Stevan W.; Wang, Ying
• Is Part Of: Angewandte Chemie. Volume 131:Number 24(2019)
• Page Start: 8071
• Page End: 8075
• Publication Date: 2019-05-07
• Subjects: Chemische Beschichtung -- Feststoffabgabe -- Glaskügelchen -- Nanomolare Reaktionen -- Reaktionsscreening; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201900536
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents on micro‐ and nanomole scale prevents the full utilization of reaction screening technologies. We herein report the development of a technology in which glass beads coated with solid chemical reagents (ChemBeads) enable the delivery of nanomole quantities of solid chemical reagents efficiently. By exploring the concept of preferred screening sets, the flexibility and generality of this technology for high‐throughput reaction screening was validated. Abstract : ChemBeads genannte Glaskügelchen, die mit festen chemischen Reagenzien beschichtet sind, ermöglichen deren effizienten Transport in nanomolaren Mengen. Anhand des Konzepts der bevorzugten Screening‐Sets wurden die Flexibilität und Allgemeingültigkeit dieser Technik für das Hochdurchsatz‐Reaktionsscreening validiert.