Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery. (17th December 2020)

• Record Type: Journal Article
• Authors: Duceppe, Emmanuelle; Lauzon, Jean‐François; Galliger, Steven; Zhang, Betty; Solomon, Hannah; Serrano, Pablo E.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 19:Number 3(2021)
• Page Start: 797
• Page End: 804
• Publication Date: 2020-12-17
• Subjects: venous thrombosis -- surgery -- postoperative complications -- observational study -- anticoagulants -- mortality; Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.15198
• Languages: English
• ISSNs: 1538-7933

Abstract

Abstract: Background: Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown. Objectives: To determine the incidence and prognosis of SVT following hepatopancreatobiliary surgery and describe current practices in anticoagulation for postoperative SVT. Patients/Methods: Multicenter retrospective cohort study of adults undergoing hepatopancreatobiliary surgery. Multivariable analyses for predictors of SVT, major bleeding, and 90‐day mortality were performed. Results: Of 1815 patients included, 89 (4.9%) had cirrhosis and 1532 (84.4%) had active cancer. The most frequent surgeries were pancreaticoduodenectomy (40.6%), open (30.7%), and laparoscopic (11.0%) liver resection. Sixty (3.3%) patients experienced SVT within 90 days of surgery. Among patients with SVT, 23.3% were symptomatic and 75.0% were treated with therapeutic anticoagulation. Planned duration of anticoagulation averaged 3 to 6 months. By multivariable analysis, SVT predictors were: operative time (adjusted odds ratio [aOR] per hour increase 1.32, 95% confidence interval [CI] 1.20‐1.46), cirrhosis (aOR 3.22, 95% CI 1.28‐8.10), and postoperative intraabdominal infection (aOR 2.99, 95% CI 1.72‐5.19). Postoperative major bleeding occurred in 22.1% of patients and 4.0% died within 90 days. Predictors of postoperative mortality were age (aOR per 10‐year increase 1.79, 95% CI 1.38‐2.30), operative time (aOR 1.31 (1.17‐1.45), cirrhosis (aOR 4.42, 95% CI 1.96‐9.96), postoperative intraabdominal infection (aOR 2.66, 95% CI 1.55‐4.57), postoperative major bleeding (aOR 4.12, 95% CI 2.36‐7.30), and postoperative SVT (aOR 3.15, 95% CI 1.42‐6.97). Conclusion: SVT occurred in 1 in 30 patients after hepatopancreatobiliary surgery and was associated with a 3‐fold independent increase in 90‐day mortality.