Narcissistic T cells: reactivity to self makes a difference. (10th August 2020)

• Record Type: Journal Article
• Authors: Paprckova, Darina; Stepanek, Ondrej
• Is Part Of: FEBS journal. Volume 288:Number 6(2021)
• Page Start: 1778
• Page End: 1788
• Publication Date: 2020-08-10
• Subjects: AIMT -- CD5 -- NUR77 -- self‐antigen -- self‐reactivity -- T cell -- TCR -- tolerance -- virtual memory; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.15498
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : It has been appreciated for more than three decades that the interactions between the T‐cell antigen receptor and self‐antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self‐reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self‐reactivity of their antigen receptors. Overall, the relative difference in the self‐reactivity among peripheral T cells is an important factor contributing to the diversity of T‐cell responses to foreign antigens. Abstract : Relative differences in T‐cell self‐reactivity result in different T‐cell fate decisions during homeostasis and during inflammation. Numerous studies have shown that different levels of self‐reactivity shape outcomes of immune responses in both CD4 + and CD8 + T‐cell populations. Here we discuss recent advances related to T‐cell self‐reactivity and their potential implications in further basic and applied research.