Acute change of cardiac autonomic regulations after thermal and non-thermal pulmonary vein ablation. (19th May 2022)

• Record Type: Journal Article
• Authors: Stojadinovic, P; Wichterle, D; Peichl, P; Cihak, R; Jansova, H; Nejedlo, V; Haskova, J; Kautzner, J
• Is Part Of: Europace. Volume 24:Supplement 1(2022)
• Publication Date: 2022-05-19
• Subjects: Arrhythmia -- Treatment -- Periodicals; Cardiac pacing -- Periodicals; Catheter ablation -- Periodicals; Heart -- Physiology -- Periodicals; Electrophysiology -- Periodicals; 617.4120645
• DOI: 10.1093/europace/euac053.232
• Languages: English
• ISSNs: 1099-5129

Abstract

Abstract: Funding Acknowledgements: Type of funding sources: None. Background: Pulmonary vein isolation (PVI) by thermal energy (radiofrequency energy or cryoenergy) results in collateral ganglionic plexi ablation. On the contrary, pulsed electric field (PEF) energy presumably spares neural tissue. Purpose: We investigated and compared the effect of PVI on parasympathetic input into the sinus node (SAN) and AV node (AVN) when four different ablation strategies were used. Methods: A study enrolled 49 patients who underwent PVI in general anesthesia (age: 57 ± 13 years, 71% males). In 17 patients, point-by-point radiofrequency energy delivery by the irritated-tip catheter was used for ablation while 7 patients were ablated using a second-generation cryoballoon catheter. In 7 patients, PEF energy was delivered using a single-shot Farawave catheter while 18 patients were ablated using Sphere9 lattice-tip catheter (Affera, Inc.); both subgroups with manufacturer-specific PEF settings. Before and after PVI, the responsiveness of the SAN and AVN was assessed by extracardiac vagal nerve stimulation (ECVS) via a diagnostic catheter in the right internal jugular vein. Five-second stimulation trains were delivered with a frequency of 50 Hz, pulse width of 0.05 ms, and output of 1 V/kg (<70V) both in sinus rhythm and during atrial pacing. Substantial reduction of response to ECVS was arbitrarily defined as a maximum induced pause of <1.5 seconds. Results: At baseline, physiological response to ECVS (long sinus arrest and/or AV block) was demonstrated. After PVI, a substantial reduction of SAN response was observed in 21/24 (88%) patients after thermal PVI and 7/25 (25%) patients after non-thermal PVI (P = 0.0001). Similarly, a substantial reduction of AVN response was observed in 21/24 (88%) patients after thermal PVI and 9/25 (36%) patients after non-thermal PVI (P = 0.0003). The Figure shows on the continuous scale the post-PVI pauses in sinus rhythm (maximum P-P interval) and atrial pacing (maximum R-R interval) induced by ECVS. Conclusion: Vagal responses of SAN and AVN are preserved in most AF patients after non-thermal PVI. This contrasts with the much stronger effect of thermal PVI. Whether this may influence the clinical outcome of AF ablation procedures remains to be investigated in future studies.