0599 Sleep duration across the lifespan in type 1 diabetes and association with cardiometabolic risk. (25th May 2022)

• Record Type: Journal Article
• Authors: Simon, Stacey; Snell-Bergeon, Janet; Schauer, Irene; Nadeau, Kristen
• Is Part Of: Sleep. Volume 45(2022)Supplement 1
• Page Start: A263
• Page End: A263
• Publication Date: 2022-05-25
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsac079.596
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Individuals with type 1 diabetes (T1D) are at high risk for morbidity and mortality from cardiovascular disease which begins as early as adolescence. Some studies have reported a high prevalence of insufficient sleep in this population which may be due to behavioral and physiological aspects of T1D and its management. Emerging evidence suggests a link between short sleep duration and increased cardiometabolic risk, but this has not been specifically examined across the lifespan in individuals with T1D. Methods: Inclusion criteria were T1D duration > 9 months, HbA1c 6.5-10% for adults and ≤ 12% for adolescents, and ages 12-60 years. Participants completed home monitoring for one week with continuous glucose monitoring (CGM) and wrist actigraphy prior to a study visit with anthropometric measurements, fasting autonomic/orthostatic and laboratory testing. Peripheral arterial stiffness was measured by Dynapulse brachial artery distensibility (BAD), and insulin sensitivity was estimated by the validated CACTI equation utilizing waist circumference, fasting triglycerides, adiponectin, and diastolic blood pressure. Sleep variables, glycemic markers and health parameters were examined by age group (adolescent vs. adult) using students t-test for univariate comparisons, and linear regression models for age, sex and diabetes duration-adjusted comparisons by age group. Results: Forty-two adolescents (mean age 16 ± 3 years, diabetes duration 7.4 ± 5 years, HbA1c 8.4 ± 1.1%) and 42 adults (mean age 41 ± 10 years, diabetes duration 21 ± 13 years, HbA1c 7.4 ± 0.9%) completed the study. Sixty-two percent of adolescents and 74% of adults obtained insufficient sleep (< 7 hours of sleep per night). When examined in linear regression adjusted for age group, sex, diabetes duration and age, insufficient sleep was associated with higher BMI (adults), BMI percentile (adolescents), waist circumference, systolic blood pressure, and lower estimated insulin sensitivity and BAD (all p < 0.05). Conclusion: Most adolescents and adults with T1D obtained insufficient sleep. Objectively-estimated insufficient sleep was associated with worse markers of cardiometabolic risk. Further study examining the impact of sleep health interventions in this population is warranted as sleep may be an important and novel target for improving cardiometabolic health in individuals with T1D. Support (If Any): JDRF grant 3-SRA-2015-125-M-R