0579 The impact of intracranial EEG on sleep is independent of whether a craniotomy was performed. (25th May 2022)

• Record Type: Journal Article
• Authors: Tyner, Kevin; Alsammani, Abdallah; Hegeman, Garnett; Stacey, William; Gliske, Stephen
• Is Part Of: Sleep. Volume 45(2022)Supplement 1
• Page Start: A255
• Page End: A255
• Publication Date: 2022-05-25
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsac079.576
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Patients with refractory epilepsy are often evaluated with intracranial electrodes prior to resection. While depth electrodes can be placed through small burr-holes, grids and strips generally require large craniotomies. We have observed many differences in patient experience between these two populations. As sleep is crucial for many aspects of health and healing, our objective was to quantify whether subjects with craniotomies had different sleep patterns. Methods: We analyzed data from N=47 patients with refractory epilepsy who underwent intracranial EEG monitoring at the University of Michigan (N = 23 with craniotomies). Sleep stages were scored by a certified sleep technician using simultaneously recorded scalp EEG. To quantify sleep patterns, we computed the fraction and average bout-length of each state of vigilance. Results: No statistical difference was found between subjects with or without craniotomies for any measure (p>0.4, Wilcoxon Rank Sum). The median fraction of time awake for all subjects was 0.70 (0.65-0.74, 95% confidence interval). However, sleep architecture appeared altered, with median fraction of sleep time in NREM 1 being 0.07(0.06-0.09), NREM 2 being 0.16 (0.13-0.17), NREM 3 being only 0.01 (0.0-0.2) and REM being 0.05 (0.04-0.06). The median bout lengths for all stages of sleep was less than 5 minutes. Conclusion: Intracranial monitoring appears to alter sleep similarly for both subjects who received craniotomies and those who had smaller burr-holes. The impact on sleep is not a significant factor when deciding between grid or depth electrodes. Support (If Any): National Institutes of Health (K01-ES026839 and R01-NS094399), and the Doris Duke Foundation (grant number 2015096).