Biodistribution and clearance of magnetoelectric nanoparticles for nanomedical applications using energy dispersive spectroscopy. (August 2017)

• Record Type: Journal Article
• Authors: Hadjikhani, Ali; Rodzinski, Alexa; Wang, Ping; Nagesetti, Abhignyan; Guduru, Rakesh; Liang, Ping; Runowicz, Carolyn; Shahbazmohamadi, Sina; Khizroev, Sakhrat
• Is Part Of: Nanomedicine. Volume 12:Number 15(2017)
• Page Start: 1801
• Page End: 1822
• Publication Date: 2017-08
• Subjects: biodistribution -- clearance -- magnetoelectric nanoparticles -- multiferroic nanoparticles -- nanomedicine; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0080
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: The biodistribution and clearance of magnetoelectric nanoparticles (MENs) in a mouse model was studied through electron energy dispersive spectroscopy.Materials & methods: This approach allows for detection of nanoparticles (NPs) in tissues with the spatial resolution of scanning electron microscopy, does not require any tissue-sensitive staining and is not limited to MENs.Results: The size-dependent biodistribution of intravenously administrated MENs was measured in vital organs such as the kidneys, liver, spleen, lungs and brain at four different postinjection times including 1 day, 1 week, 4 and 8 weeks, respectively.Conclusion: The smallest NPs, 10-nm MENs, were cleared relatively rapidly and uniformly across the organs, while the clearance of the larger NPs, 100- and 600-nm MENs, was highly nonlinear with time and nonuniform across the organs.