Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population. (March 2017)

• Record Type: Journal Article
• Authors: Hu, Guo-Xin; Dai, Da-Peng; Wang, Hao; Huang, Xiang-Xin; Zhou, Xiao-Yang; Cai, Jie; Chen, Hao; Cai, Jian-Ping
• Is Part Of: Pharmacogenomics. Volume 18:Number 4(2017)
• Page Start: 369
• Page End: 379
• Publication Date: 2017-03
• Subjects: CYP3A4 -- genetic polymorphism -- Han Chinese population -- novel allelic variants; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2016-0179
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population.Materials & methods: The promoter and exons of CYP3A4 gene in 1114 unrelated, healthy Han Chinese subjects were amplified and genotyped by direct sequencing.Results: In total, five previously reported alleles ( *1G, *4, *5, *18B and *23 ) were detected, of which one allele ( *23 ) was reported for the first time in Han Chinese population. Additionally, seven novel exonic variants were also identified and designated as new alleles CYP3A4*28–*34 .Conclusion: This study provides the most comprehensive data of CYP3A4 polymorphisms in Han Chinese population and detects the largest number of novel CYP3A4 alleles in one ethnic group.