Genetic variants associated with warfarin dosage in Kuwaiti population. (June 2017)

• Record Type: Journal Article
• Authors: John, Sumi Elsa; Antony, Dinu; Eaaswarkhanth, Muthukrishnan; Hebbar, Prashantha; Alkayal, Fadi; Tuomilehto, Jaakko; Alsmadi, Osama; Thanaraj, Thangavel Alphonse
• Is Part Of: Pharmacogenomics. Volume 18:Number 8(2017)
• Page Start: 757
• Page End: 764
• Publication Date: 2017-06
• Subjects: anticoagulation -- Arab population -- CYP2A7 -- CYP4F2 -- exome -- genetic variants -- Kuwait -- PRSS53 -- VKORC1 -- warfarin; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0020
• Languages: English
• ISSNs: 1462-2416

Abstract

Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590_A/ CYP2A7, rs2108622_T/ CYP4F2, rs2884737_C/ VKORC1 and distinct absence of rs11150606_C/ PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.