Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns. Issue 1 (18th September 2015)

• Record Type: Journal Article
• Authors: Mansilla, Eduardo; Marín, Gustavo H.; Berges, Mirta; Scafatti, Silvia; Rivas, Jaime; Núñez, Andrea; Menvielle, Martin; Lamonega, Roberto; Gardiner, Cecilia; Drago, Hugo; Sturla, Flavio; Portas, Mercedes; Bossi, Silvia; Castuma, Maria Victoria; Peña Luengas, Sandra; Roque, Gustavo; Martire, Karina; Tau, Jose Maria; Orlandi, Gabriel; Tarditti, Adrian
• Is Part Of: Burns and trauma. Volume 3:Issue 1(2015)
• Publication Date: 2015-09-18
• Subjects: Burns -- Cadaveric -- Transplantation -- Skin regeneration -- Mesenchymal stem cells; Burns and scalds -- Periodicals; Wounds and injuries -- Periodicals; 617.11
• DOI: 10.1186/s41038-015-0018-4
• Languages: English
• ISSNs: 2321-3876

Abstract

Abstract: Background: In January 2005, Rasulov et al. originally published "First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns". Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine. Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns while working with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry of Health, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after early escharotomy. Results: So far, our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of CMSCs. Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the world. CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.