Microwave-assisted synthesis of fused piperazine-benzimidazoles via a facile, one-pot procedure. Issue 31 (29th July 2015)

• Record Type: Journal Article
• Authors: Song, Gui-Ting; Li, Shi-Qiang; Yang, Zhi-Wei; Yuan, Jian-Hui; Wang, Ming-Shu; Zhu, Jin; Chen, Zhong-Zhu; Xu, Zhi-Gang
• Is Part Of: Tetrahedron letters. Volume 56:Issue 31(2015)
• Page Start: 4616
• Page End: 4618
• Publication Date: 2015-07-29
• Subjects: Fused piperazine-benzimidazole -- Microwave irradiation -- UDC strategy -- Nucleophilic substitution reaction -- One-pot procedure; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.06.035
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Two series of compounds containing fused piperazine-benzimidazole scaffolds have been synthesized using an Ugi/deprotection/cyclization strategy (UDC) followed by an intermolecular nucleophilic substitution reaction. This new strategy allows for the facile synthesis of compounds in a one-pot reaction giving fused piperazine-benzimidazoles in good yields. This synthetic strategy can be readily applied to the construction of a diverse range of compounds for high throughput screening in medicinal chemistry.