A simple one-pot preparation of N-allenyl amides, ureas, carbamates and sulfonamides using a DMSO/tBuOK protocol. Issue 2 (8th January 2015)

• Record Type: Journal Article
• Authors: Bousfield, Thomas W.; Kimber, Marc C.
• Is Part Of: Tetrahedron letters. Volume 56:Issue 2(2015)
• Page Start: 350
• Page End: 352
• Publication Date: 2015-01-08
• Subjects: Amide -- Allenamide -- Propargyl bromide -- One-pot -- Lactam; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2014.11.093
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A one-pot transformation of amides, ureas, carbamates and sulfonamides into synthetically useful N -allenyl analogues using a t BuOK/DMSO protocol is reported. The procedure is experimentally simple and robust, and provides N -allenyl analogues, commonly used within the literature, in yields comparable to the benchmark two-step approach.