Diastereoselective synthesis of spirooxindole derivatives via biocatalytic domino reaction. Issue 4 (28th January 2015)
- Record Type:
- Journal Article
- Title:
- Diastereoselective synthesis of spirooxindole derivatives via biocatalytic domino reaction. Issue 4 (28th January 2015)
- Main Title:
- Diastereoselective synthesis of spirooxindole derivatives via biocatalytic domino reaction
- Authors:
- Liang, Yi-Ru
Chen, Xiao-Yang
Wu, Qi
Lin, Xian-Fu - Abstract:
- Abstract: A facile promiscuous reaction catalyzed by Acylase 'Amano' was developed for the preparation of spirooxindole derivatives. At the optimized reaction condition, the acylase-catalyzed domino reactions could provide a series of different spirooxindole products in moderate yields and good diastereoselectivity. A chemo-enzymatic two-step process was also designed successfully, and several representative spirooxindole derivatives could be obtained in nearly quantitative yields. Additionally, one tentative mechanism for this enzyme-catalyzed process was proposed. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 4(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 4(2015)
- Issue Display:
- Volume 71, Issue 4 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 4
- Issue Sort Value:
- 2015-0071-0004-0000
- Page Start:
- 616
- Page End:
- 621
- Publication Date:
- 2015-01-28
- Subjects:
- Spirooxindole -- Acylase -- Domino reaction -- Diastereoselectivity
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2014.12.027 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 21997.xml