A convenient aqueous copper-catalyzed synthesis of quinazolinones. Issue 29 (22nd July 2015)

• Record Type: Journal Article
• Authors: Xu, Yulong; Xie, Qiong; Li, Wei; Sun, Hongpeng; Wang, Yonghui; Shao, Liming
• Is Part Of: Tetrahedron. Volume 71:Issue 29(2015)
• Page Start: 4853
• Page End: 4858
• Publication Date: 2015-07-22
• Subjects: Coupling reactions -- Aqueous micellar -- Quinazolinone -- Recycled -- E factors; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2015.05.011
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A simple and highly efficient method for the aqueous copper-catalyzed coupling reactions with the aid of a commercially available surfactant (TPGS-750-M) is reported. In an aqueous micellar medium, 2-halobenzoic acids derivatives reacted with amidines and guanidines and generated the corresponding quinazolinone derivatives in good to excellent yields in the range of room temperature to, at most, 50 °C. In addition, the reaction medium can be recycled, and this method led to a significant improvement of the E factors in comparison with the previously reported process. Graphical abstract: