Agelamadin F and tauroacidin E, bromopyrrole alkaloids from an Okinawan marine sponge Agelas sp. Issue 30 (22nd July 2015)

• Record Type: Journal Article
• Authors: Kusama, Taishi; Tanaka, Naonobu; Kashiwada, Yoshiki; Kobayashi, Jun'ichi
• Is Part Of: Tetrahedron letters. Volume 56:Issue 30(2015)
• Page Start: 4502
• Page End: 4504
• Publication Date: 2015-07-22
• Subjects: Marine sponge -- Agelas sp. -- Bromopyrrole alkaloid -- Agelamadin F -- Tauroacidin E; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.05.114
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A new structurally unique bromopyrrole alkaloid, agelamadin F (1 ), comprising oroidin and 3-hydroxypyridinium was isolated from an Okinawan marine sponge Agelas sp. together with tauroacidin E (2 ), a new bromopyrrole alkaloid possessing a taurine moiety. Six known bromopyrrole alkaloids, oroidin, tauroacidin A, sceptrin, ageliferin, nagelamide E, and agelongine were also isolated and identified. The structures of 1 and 2 were elucidated on the basis of spectroscopic evidences, while chiral HPLC analysis suggested tauroacidin E (2 ) to be a racemate.