An efficient one-pot two-step three-component process for the synthesis of perfluoroalkylated biphenyls. Issue 5 (4th February 2015)

• Record Type: Journal Article
• Authors: Xu, Yuhong; Han, Jing; Lv, You; Pan, Renming; Chen, Jie; Deng, Hongmei; Shao, Min; Zhang, Hui; Cao, Weiguo
• Is Part Of: Tetrahedron. Volume 71:Issue 5(2015)
• Page Start: 820
• Page End: 825
• Publication Date: 2015-02-04
• Subjects: Biphenyl -- MCR -- Perfluoroalkylated -- One-pot reaction; PZSALSIUUHXJAR-UHFFFAOYSA-N -- WYECURVXVYPVAT-UHFFFAOYSA-N -- UGWSDUBTSCECEK-UHFFFAOYSA-N -- XKWLMVTXPRGWNS-UHFFFAOYSA-N -- PIMNFNXBTGPCIL-UHFFFAOYSA-N -- KWOLFJPFCHCOCG-UHFFFAOYSA-N -- WTERCTGKTLCWGO-UHFFFAOYSA-N -- HZJHTABUUADVMQ-UHFFFAOYSA-N -- FSPSELPMWGWDRY-UHFFFAOYSA-N -- INGUGCUNXULGMA-UHFFFAOYSA-N -- WSAUJXUTZTZKEV-UHFFFAOYSA-N -- BUZYGTVTZYSBCU-UHFFFAOYSA-N -- XYIQHQMCGMLZNW-UHFFFAOYSA-N -- OQZYWRQWMOFBRL-UHFFFAOYSA-N -- HPEUMPBWTQKNKV-UHFFFAOYSA-N -- ZDOYHCIRUPHUHN-UHFFFAOYSA-N -- ITLOTIHZMHPJDW-UHFFFAOYSA-N -- CEOIUSFSPHGRGM-UHFFFAOYSA-N -- NTPLXRHDUXRPNE-UHFFFAOYSA-N -- PYLCECZCEBEZHO-UHFFFAOYSA-N -- LASRSWTWZRNXTP-UHFFFAOYSA-N -- PNCGVVFGJUTEOU-UHFFFAOYSA-N -- GNKZMNRKLCTJAY-UHFFFAOYSA-N -- OQVNOLNPARFALS-UHFFFAOYSA-N -- TVGNWCVZYHKRFD-UHFFFAOYSA-N -- WTCDDBZNOJYAME-UHFFFAOYSA-N -- YXWWHNCQZBVZPV-UHFFFAOYSA-N; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2014.12.051
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A practical and economical process for the synthesis of perfluoroalkylated biphenyl derivatives has been developed. The three-component reaction of aromatic ketones, malononitrile and methyl perfluoroalk-2-ynoates gave the desired products in good to excellent yields via a one-pot two-step process. Graphical abstract: