MSP: An emerging player in metabolic syndrome. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Li, Jieyi; Chanda, Dipanjan; Shiri-Sverdlov, Ronit; Neumann, Dietbert
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 1(2015)
• Page Start: 75
• Page End: 82
• Publication Date: 2015-02
• Subjects: MSP macrophage stimulating protein -- HGF hepatocyte growth factor -- HGFL hepatocyte growth like factor -- NGF-γ nerve growth factor-γ -- EGF-BP epidermal growth factor-binding protein -- HGFA hepatocyte growth factor activator -- HAT human airway trypsin-like protease -- MT-SP1 membrane type serine protease 1 -- receptor tyrosine kinase RON receptor tyrosine kinase Recepteur d'Origine Nantais -- C3bi complement component C3 fragment -- C5a complement component C5 fragment -- iNOS inducible nitric oxide synthase -- IFN-γ interferon-γ -- NO nitric oxide -- Cox-2 Cyclooxygenase-2 -- PGE2 prostaglandin E2 -- NF-κB nuclear factor kappa B -- LPS lipopolysaccharide -- STAT-1 signal transducer and activator of transcription 1 -- IκBα nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -- IKK-β inhibitor of nuclear factor kappa-B kinase subunit, beta -- IL-12 interleukin 12 -- NK cells natural killer cell -- TNF-α tumor necrosis factor-alpha -- SHP small heterodimer partner -- LKB1 liver kinase B1 -- AMPK AMP-activated protein kinase -- BMDMs bone marrow derived macrophages -- TLR Toll-like receptors -- TRAF6 TNF receptor associated factor 6 -- IL-10 interleukin 10 -- SOD superoxide dismutase -- GalN galactosamine -- IBD inflammatory bowel disease -- MST1 macrophage stimulating 1 -- ALI acute lung injury -- Dex dexamethasone -- PEPCK phosphoenolpyruvate carboxykinase -- Glc-6-Pase glucose-6-phosphatase -- JNK c-Jun N-terminal kinases -- RTKs receptor tyrosine kinases -- c-Met mesenchymal-epithelial transition factor -- T2DM type 2 diabetes mellitus -- Glut 1 glucose transporter 1 -- Glut 4 glucose transpoter 4 -- INSR insulin receptor -- MCD methionine-choline deficient diet -- NASH non-alcoholic steatohepatitis; MSP -- RON -- Inflammation -- Metabolic syndrome; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2014.10.007
• Languages: English
• ISSNs: 1359-6101

Abstract

Highlights: MSP is a key negative regulator in inflammation in multiple disease models. MSP has potential beneficial effects in regulation of lipid and glucose metabolism. MSP may possibly act as a crucial regulator of metabolic syndrome. Abstract: MSP (Macrophage Stimulating Protein; also known as Hepatocyte Growth Factor-like protein (HGFL) and MST1) is a secreted protein and the ligand for transmembrane receptor tyrosine kinase Recepteur d'Origine Nantais (RON; also known as MST1R). Since its discovery, MSP has been demonstrated to play a key role in regulating inflammation in the peripheral tissues of multiple disease models. Recent evidences also point toward a beneficial role of MSP in the regulation of hepatic lipid and glucose metabolism, thereby implicating MSP as a crucial regulator in maintaining metabolic homeostasis while simultaneously suppressing inflammatory processes. In this review, we discuss the recent advances that demonstrate the significance of MSP in metabolic syndrome and build a strong case supporting its therapeutic potential.